منابع مشابه
Novel agents for anti-platelet therapy
Anti-platelet therapy plays an important role in the treatment of patients with thrombotic diseases. The most commonly used anti-platelet drugs, namely, aspirin, ticlopidine, and clopidogrel, are effective in the prevention and treatment of cardio-cerebrovascular diseases. Glycoprotein IIb/IIIa antagonists (e.g., abciximab, eptifibatide and tirofiban) have demonstrated good clinical benefits an...
متن کاملAnti-platelet therapy: ADP receptor antagonists
The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis. Agents that act as antagonists at this receptor are thus likely to provide effective antithrombotic therapy, provided that there are no adverse effects on haemostasis. Here we describe the ADP receptor antagonists th...
متن کاملAnti-platelet therapy for Acute Coronary Syndrome
The term ‘Acute Coronary Syndrome’ (ACS) refers to a range of acute myocardial ischaemic states which include unstable angina, non ST segment elevation myocardial infarction (NSTEMI) and ST segment elevation myocardial infarction (STEMI). Despite significant advances in the diagnosis and management, ACS remains a significant global problem with very high mortality and morbidity. The pathogeneti...
متن کاملAnti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets
PURPOSE Altered platelet aggregability has been implicated in the pathogenesis of glaucoma. This study aims to investigate the anti-platelet potential of intraocular pressure lowering drops, with the possibility of establishing it as an additional mechanism of anti-glaucomatous action. MATERIALS AND METHODS The anti-aggregating effects of a series of anti-glaucomatous eye drops were determine...
متن کاملMicroparticle Formation and Platelet Shrinkage in Type-I Glanzmman Thrombasthenia Platelets
Background: Activated normal platelets undergo many biochemical and morphological changes, some of which are apoptotic. Platelet derived microparticles and shrinked platelets as hallmark of platelet activation and apoptosis disperse surfaces containing procoagulant activity around injured vessels and tissues. This study was conducted to determine microparticles formation and platelet shrinkage ...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2003
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.93.381